Wrinkle-Relaxing Neuromodulators

Neuromodulators are highly effective products in cosmetic dermatology used to smooth wrinkles and fine lines. These injectables are particularly beneficial for dynamic wrinkles, which are lines that manifest due to repetitive muscle movements. These muscle contractions occur when we make facial expressions like smiling or frowning, and the lines can become etched into our skin over time and remain there even when our faces are at rest.

By temporarily blocking nerve signals that prompt muscle contractions, neuromodulators help relax the targeted facial muscles, reducing the appearance of age-related creases. The result is enhanced skin smoothness and a more youthful and refreshed look.

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Dr. Joel L. Cohen: A Leading Expert in Neuromodulator Research, Education and Clinical Applications

AboutSkin Dermatology and Aesthetics is a premier, nationally recognized aesthetic and dermatology center in the Denver area. Our director, Dr. Joel L. Cohen, a Board-Certified Dermatologist, is a key figure in the field of dermatology with a robust background in neuromodulator research and education.

Dr. Cohen completed a fellowship with Dr. Osman Wife, the pioneer in the cosmetic use of Botox, which significantly enriched his expertise in this specialized area. Dr. Cohen has also written three textbooks, including one of the largest, most groundbreaking textbooks on Botox and its related competing products (Botulinum Toxins: Cosmetic and Clinical Applications), and over 262 articles on Botox and related aesthetic treatments. In addition, Dr. Cohen has led clinical trials on all of the currently available neuromodulators in the U.S. Globally recognized for his extensive contributions, Dr. Cohen has been teaching lectures and courses regularly for over 21 years, every month regionally or nationally and two or three times a year internationally, underscoring his profound impact on the field.

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Neuromodulator Options at AboutSkin

At AboutSkin Dermatology and Aesthetics, we offer three leading neuromodulator options: Botox, Dysport and Daxxify. Each has unique characteristics tailored to meet different needs and preferences.

BOTOX® Cosmetic

Botox is perhaps the most well-known neuromodulator on the market and has been a staple in cosmetic treatment for decades. Many patients choose Botox for its proven track record and efficacy. It’s derived from botulinum toxin type A and is FDA-approved for reducing the appearance of facial wrinkles. Botox is particularly effective for treating crow’s feet around the eyes and frown lines between the eyebrows.

Botox results generally become noticeable within three to four days and peak around 10 to 12 days. The majority of patients experience smoother skin for up to four months.


Dysport is another FDA-approved botulinum toxin type A product. It’s specifically formulated to spread a little more than Botox, making it ideal for larger treatment areas, such as the forehead.

Although similar to Botox, some patients find that Dysport works faster, with results noticeable within a couple of days of treatment. This can be particularly appealing for those who desire quick results, such as when preparing for an upcoming social event. Like the effects of Botox, Dysport results typically last three to four months.


Daxxify is the latest addition to the neuromodulator family and is known for its long-lasting effects. Like Botox and Dysport, Daxxify is derived from botulinum toxin type A and is FDA-approved for reducing the appearance of facial wrinkles. It is particularly effective for treating prominent forehead lines and frown lines between the eyebrows, making it a strong option for those looking for enduring aesthetic improvements.

Daxxify’s effects are notable for their onset and duration. Results typically become apparent within a few days, similar to Dysport, with peak effects observable shortly thereafter. What sets Daxxify apart is its durability; the effects can last up to six months, significantly longer than most other neuromodulators. This extended period can reduce the frequency of treatments needed, which is highly beneficial for individuals with busy schedules.

Learn More About Neuromodulators Near Denver, CO

At AboutSkin Dermatology and Aesthetics, our team of skilled, Board-Certified Dermatologists is committed to providing personalized care and the latest advancements in dermatological treatments. Whether you’re new to neuromodulators or looking for a change in your aesthetic routine, our expert team is here to guide you through your options.

Schedule your consultation today to find out which neuromodulator is right for you.

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Greenwood Village Office

5340 South Quebec ST., STE. 300 (South Entrance)
Greenwood Village, CO 80111

(303) 756-7546

Sky Ridge Medical Center

10099 Ridgegate Parkway, Ste. 490 (Conifer Building)
Lone Tree, CO 80124

(303) 756-7546

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