The recognition that inflammation is at the heart of acne has led to changes in management approaches and better understanding of how treatments work. In the first of a 2-part series, host Joel L. Cohen, MD talks to Diane Berson, MD; Linda Stein Gold, MD; and Emil Tanghetti, MD about acne approaches, with a focus on the latest in topical interventions. They address hot topics, including bacterial resistance and variations in treatment response across different patient populations.