From the optimal, safe use of isotretinoin to the proper role for systemic antibiotics and beyond, there are multiple areas of systemic acne care that deserve attention. In the second of a 2-part series, host Joel L. Cohen, MD talks to Diane Berson, MD; Linda Stein Gold, MD; and Emil Tanghetti, MD about best practices in acne care, with a focus on identifying and countering misinformation.